![]() In this case, the log-enrichment is a real-valued number that is meant to characterize how much each gene or transcript abundance differs between the two conditions-the larger the log-enrichment for a transcript, the more it is believed this transcript is relevant to explaining changes between the two conditions. For example, log-enrichment estimation is performed in differential analyses of RNA-seq and ATAC-seq experiments to quantitatively compare gene- or transcript-level expression-based on sequencing counts-between, for instance, a “normal” control condition and a gene knockdown condition that corresponds to the control condition except that a particular gene has been knocked out . This type of quantification is often referred to as estimating the “log-enrichment” of a sequence between two conditions . Across many of these scientific areas, a key desired outcome from a high-throughput sequencing experiment is to quantify the change in relative abundance of a particular sequence between two conditions for a large number of distinct sequences. As a consequence, high-throughput sequencing has dramatically changed the landscape of biological discovery-both for basic scientific inquiry into cellular transcriptomes and protein behavior and evolution , and in application areas spanning human disease and variant detection , engineering anti-viral immunogens and therapeutics , drug and antibiotic resistance , regulatory element engineering in synthetic biology and beyond. Don't like that.Using next-generation sequencing, we can now assay up to billions of DNA or RNA sequences in parallel for an ever-expanding set of properties of interest . One plus with the mighty mouse is the side buttons have become "desktop" with expose. But I can't get the mightymouse to do that with web pages. One thing about the Logitech (5 button mouse) it has this nice feature where clicking the wheel and dragging will also scroll web pages, either direction, in the same manner that this function works in Logic. But that right click "button" on the mighty mouse is definitely fiddly, you actually have to lift your finger OFF the left side of the mouse to make the right click work properly! Not the greatest way of implemetning it, Apple. You can just nudge it gently and hold the mouse still and watch the window slooowly scroll by if you want. ![]() The one thing I love now is if I want to scroll smoothly one way or the other in a Logic window, I hold down the mouse wheel (ball) and drag just like I've always done with shift-control drag before. But I had the old one button mouse before so this is definitely an improvement. I'm kind of wondering why I bothered, rather than get a regular three or five button mouse from Kensington or Logitech. *This behavior has changed in Logic Pro 7.1: now you simply move the mouse in the direction you want the window to move, just like a 2D scrollbar. ![]() so to get your brain in sync with what you're doing, picture yourself "grabbing" the editor through the window and moving it around, much like you would grab a microfilm and move it around to see what you want through the window. Note: Surfing in Logic can be a little disconcerting at first: moving the mouse to the left moves the editor window to the right, moving the mouse up moves the window downwards. SURF! For advanced surfing, try moving both down and right, up and left. Move the mouse up, down, left or right and. Now to really "SURF" the Editors in Logic, simply hold Control + Shift while clicking in the background. ![]() Option+Command + Scroll: Horizontal Zoom In/Out If you are the lucky owner of a scroll-wheel mouse (who isn't?), then you can easily navigate Logic's editor windows using these shortcuts:Ĭommand + Shift + Scroll: Move Left/Right ![]()
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